Indications for use: Symptomatic treatment of flu and cold symptoms (hyperthermia, headache, rhinitis, cough) in adults and children over 12 years of age.

Contraindication: Hypersensitivity to paracetamol, caffeine, other xanthine derivatives (theophylline, theobromine) or to other components of the drug, especially parabens (methyl- and propylparaben). Severe disorders of liver and kidney function (including liver and kidney failure); congenital hyperbilirubinemia (including Gilbert, Dubin-Johnson, Rotor syndrome); glucose-6-phosphate dehydrogenase deficiency, rare hereditary forms of fructose intolerance, glucose-galactose malabsorption or sucrose-isomaltase deficiency.

Alcoholism. Blood formation disorders, blood diseases, severe anemia, leukopenia, thrombosis, thrombophlebitis. States of increased excitement, sleep disturbances.

Severe cardiovascular diseases. Severe arterial hypertension, pronounced increase in blood pressure, organic diseases of the cardiovascular system (including atherosclerosis); decompensated heart failure; cardiac conduction disorders; paroxysmal tachycardia, arrhythmia; tendency to spasm of blood vessels; ischemic heart disease, acute myocardial infarction.

Glaucoma, including angle-closure glaucoma. Acute pancreatitis. Prostate hypertrophy. Pheochromocytoma. Bladder neck obstruction.

Diabetes. Epilepsy. Hyperthyroidism.

Pyloroduodenal obstruction, gastric and duodenal ulcer in the acute stage, stenotic gastric ulcer, stenotic duodenal ulcer, acute pancreatitis and hepatitis. Bronchial asthma, chronic obstructive pulmonary disease. Risk of respiratory failure.

Age over 60 years. Children's age up to 12 years. The period of pregnancy and breastfeeding.

Do not use together with monoamine oxidase (MAO) inhibitors and within 2 weeks after stopping the use of MAO inhibitors.

Contraindicated in patients taking tricyclic antidepressants or beta-blockers.

Do not use in patients with phenylketonuria. It is not recommended to be used by patients with an increased level of blood coagulation, a tendency to blood clots.

Do not use together with drugs that suppress or increase appetite and amphetamine-like psychostimulants.