Indications for use: Bleeding or risk of bleeding with increased fibrinolysis, both generalized and local in adults and children over 1 year of age.
Specific indications include:
- bleeding caused by increased general or local fibrinolysis, such as:
- menorrhagia and metrorrhagia;
- gastrointestinal bleeding;
- hemorrhagic disorders of the urinary tract, which occurred in connection with surgical intervention on the prostate gland or as a result of surgical intervention or procedures on the urinary tract;
- otolaryngological (removal of adenoids, tonsillectomy) and stomatological (extraction of teeth) surgical interventions;
- gynecological operations or complications in obstetric practice;
- thoracic, abdominal and other major surgical interventions, for example, cardiovascular surgery;
- control of hemorrhages in connection with the administration of a fibrinolytic drug.

Contraindication: Hypersensitivity to the active substance or to any of the components of the drug. Acute venous or arterial thrombosis. Fibrinolytic conditions with acute heavy bleeding due to the introduction of coagulopathic agents (anticoagulants), with the exception of drugs that mainly activate the fibrinolytic system. Severe renal failure (there is a risk of drug accumulation). Seizures in history. Intrathecal and intraventricular injection, intracerebral injection (risk of cerebral edema with subsequent development of convulsions).